The listings featured on this site are from companies from which this site receives compensation. This influences where, how and in what order such listings appear on this site. Advertising Disclosure

Understanding Hormone Replacement Therapy: What It Is and How It Works

CompareTreatments Editorial Team

March 2, 2026

Hormone Replacement Therapy (HRT) is a medical treatment used to help manage symptoms caused by changes in hormone levels. It is most commonly discussed during menopause, when the body naturally produces lower amounts of hormones such as estrogen and progesterone. Menopause is a natural life stage that typically occurs between the ages of 45 and 55, although timing can vary. As hormone levels shift during perimenopause (the transitional years leading up to menopause) and after menopause, some individuals experience physical and emotional symptoms that can affect daily life. HRT is one option that healthcare providers may discuss to help manage these changes in appropriate candidates.


What Hormone Replacement Therapy Does

HRT works by supplementing hormones that the body may produce in lower amounts over time. The goal is to help stabilize hormone levels enough to reduce certain symptoms while using the lowest effective dose for the shortest appropriate duration, based on individual health factors.

This may help address symptoms that sometimes occur during hormonal transitions, including hot flashes, night sweats, sleep disturbances, and vaginal dryness. Some people also report mood changes, brain fog, joint discomfort, or decreased libido during menopause, and hormone therapy may help relieve some of these concerns in certain cases.


Common Types of Hormone Therapy

Healthcare providers may recommend different types of HRT depending on a person’s symptoms, whether they still have a uterus, their risk factors, and their overall medical history. The two most commonly discussed approaches include:

  • Estrogen-only therapy
  • Combined therapy, which includes both estrogen and progesterone

Estrogen-only therapy is generally prescribed for individuals who have had a hysterectomy (surgical removal of the uterus), since estrogen alone can increase the risk of endometrial (uterine) cancer in those who still have a uterus.

Combined therapy includes both estrogen and progesterone (or a similar hormone called progestin). Progesterone helps protect the lining of the uterus from overgrowth, reducing the risk of endometrial cancer when estrogen is used. Combined therapy may be given in continuous or cyclic regimens, depending on individual needs and provider recommendations.


Why People Research HRT

Many people research hormone replacement therapy to better understand treatment options and possible considerations before speaking with a healthcare professional. Because HRT has been widely discussed in the media over the years, individuals often seek clear, evidence-based information about potential benefits and risks.

CompareTreatments.com provides educational resources that explain common hormone therapy approaches and treatment categories.

Compare Treatments